Persistent
sad, anxious, or “empty” mood
Feelings of hopelessness,
pessimism
Feelings of guilt, worthlessness,
helplessness
Loss of interest or pleasure in
hobbies and activities that were once enjoyed, including sex
Decreased energy, fatigue, being
“slowed down”
Difficulty concentrating,
remembering, making decisions
Trouble sleeping, early-morning
awakening, or oversleeping
Appetite and/or weight changes
Thoughts of death or suicide, or
suicide attempts
Restlessness, irritability
Persistent physical symptoms,
such as headaches, digestive disorders, and chronic pain, which do
not respond to routine treatment.
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