Clinical studies have shown few if any side effects among those who have been given Alpha Lipoic Acid supplements as directed. Higher doses can cause nausea and upset stomachs, and excessive doses can even lead to low blood sugar. One positive side effect of taking Alpha Lipoic Acid is a mild and relaxed feeling, also described as a sense of well-being, reported by some who have taken this supplement.

At higher doses, Alpha-Lipoic Acid, like any other antioxidant, can reduce minerals from your body. In one study, iron in participants blood was shown to decrease significantly. For age-related treatment, this may be helpful in reducing the production of free-radicals. According to Tory Hagen, Ph.D of Linus Pauling Institute, Alpha lipoic acid is currently being researched for reducing the metal-related oxidant stress and slow the progression of alzheimer's disease. You and your doctor should monitor iron levels with regular blood tests if you are planning to take high doses of alpha lipoic acid.